Sebaceous Adenocarcinoma


Sebaceous adenocarcinomas arise from meibomian glands, glands of Zeis, and other sebaceous glands around the eyelids.  Patients with this type of cancer are usually elderly women who present with erythematous, painless, firm lid nodules with associated lash disruption, conjunctival thickening via pagetoid spread, and enlarged preauricular nodes.  Associated mortality is 10%.  Management of this condition includes full thickness biopsy of the lesion with lipid stain, sentinel node biopsy, radiotherapy, and exenteration in cases of multifocal disease and if the septum is breached.